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Open Access Green as soon as Postprint is submitted to ZB.
Drosophila nicastrin is essential for the intramembranous cleavage of notch.
Dev. Cell 2, 79-89 (2002)
The catalytic subunit of gamma-secretase is thought to be Presenilin, which is required for both the cleavage of APP and in the processing of Notch. Presenilin is found in a multisubunit complex that also contains Nicastrin. Nicastrin has been implicated in APP processing, but its role in Notch signaling remains unclear. Here we show that Drosophila Nicastrin is required for Notch signaling, and acts specifically at the S3 cleavage step. Partially processed Notch accumulates apically in nicastrin and presenilin mutant follicle cells. nicastrin and presenilin mutations also disrupt the spectrin cytoskeleton, suggesting that the gamma-secretase complex has another function in Drosophila in addition to its role in processing Notch and APP.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2002
HGF-reported in Year
0
ISSN (print) / ISBN
1534-5807
e-ISSN
1878-1551
Journal
Developmental Cell
Quellenangaben
Volume: 2,
Issue: 1,
Pages: 79-89
Publisher
Elsevier
Reviewing status
Peer reviewed
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-500100-001
PubMed ID
11782316
Erfassungsdatum
2002-12-31