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Gräber, M.* ; Hell, M.* ; Grost, C.* ; Friberg, A. ; Sperl, B.* ; Sattler, M. ; Berg, T.*

Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells.

Angew. Chem.-Int. Edit. 52, 4487-4491 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Chlorhexidine and alexidine have long been used as oral disinfectants by humans. Both compounds inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL at physiologically relevant concentrations and induce apoptosis in a series of tumor cell lines derived from the tongue and pharynx (see picture). Inhibition of protein-protein interactions is a potential mode of action of drugs in current human use. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Antitumor Agents ; Apoptosis ; Drug Discovery ; Inhibitors ; Protein-protein Interactions; Bcl-2 Family ; Fluorescence Polarization ; Antagonists ; Optimization ; Recognition ; Antiseptics ; Alexidine ; Domains ; Assay
ISSN (print) / ISBN 1433-7851
e-ISSN 1521-3773
Journal Angewandte Chemie - Internationale Edition
Quellenangaben Volume: 52, Issue: 16, Pages: 4487-4491 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed
Institute(s) Institute of Structural Biology (STB)