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Prinzip, Technik und Indikation der Hyperthermie und Teilkörperhyperthermie.
Radiologe 44, 301-309 (2004)
Clinical hyperthermia with controlled alteration of temperature (40 to 44°C) in the target area is used in interdisciplinary treatment concepts for tumor treatment in combination with radiation and/or radiotherapy. Besides the direct cytotoxic power of hyperthermia there is an immunmodulatory effect and a radiation and chemotherapy sensitizing effect in the heated tissue. Clinical hyperthermia is an invasive or non-invasive supply of energy to the body of the patient, which leads to an artificial heating of the tumor and the surrounded tissue. The clinical hyperthermic procedures should take into account the oncologic disease and its pattern of organ involvement. There are three different types of hyperhermia: local hyperthermia (LHT), regional hyperthermia (RHT) and part body hyperthermia (PBH). PBH is used to heat regions of the body in case of metastatic disease, e. g. to the abdomen. Phase I and phase II trials could show that the effects of radiation and chemotherapy can be altered by the simultaneous addition of hyperthermia. Data of trials involving skin metastasis in malignant melanoma, local relapse in breast cancer, tumors of the head and neck with regional lymph node metastasis, as well as trials in colorectal tumors, bladder cancer, pancreatic cancer, cervical cancer and sarcoma are presented. The results shows, that response to treatment can be improved by hyperthermia.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hyperthermia, state of the art - Part body hyperthermia - Simultaneous MRI - Tumor therapy - Phase II/III trials
Language
german
Publication Year
2004
HGF-reported in Year
2004
ISSN (print) / ISBN
0033-832X
e-ISSN
1432-2102
Journal
Radiologe, Der
Quellenangaben
Volume: 44,
Issue: 4,
Pages: 301-309
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-521100-001
Scopus ID
2442553756
Erfassungsdatum
2004-05-12