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Lin, S.-X.* ; Poirier, D.* ; Adamski, J.

A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: An integrated biological function and inhibition study.

Curr. Top. Med. Chem. 13, 1164-1171 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Members of the 17β-hydroxysteroid dehydrogenase (17β-HSD) superfamily perform distinct multiple catalyses by the same enzyme, apparently contradictory to the long-held beliefs regarding the high specificity of enzymes. Surprisingly, these multi-catalyses can combine synergistically in vitro and in vivo and their dysfunction may result in the stimulation of breast or prostate cancer. 17β-HSD1 possesses high estrogen activation activity, while its androgen inactivation is significant for decreasing the nM concentration of dihydrotestosterone (DHT) in breast cancer cells, an important factor for cell proliferation. 17β-HSD5 can also carry out multiple catalyses in hormone-dependent cancer cells. In addition to 17β-HSDs 1 and 5 some other family members possess such dual-activity as well, and their inhibition decreases hormone-dependent cancer proliferation. The multi-specificity of 17β-HSD1 is structurally based on the pseudo-symmetric androgens that can accommodate the narrow enzyme substrate tunnel by both normal and alternative binding. The atypical family member 17β-HSD5 possesses a spacious binding site, which is accessible to several substrates. Expression of 17β-HSD1 can also control other estrogen-responsive elements such as pS2, and can regulate steroid-hormone receptors. The fundamental involvement of 17β-HSD1 in catalysis and gene regulation underlies its close relationship to breast cancer, attributable to its long evolutionary process. These observations stimulated detailed study of steroid-converting enzyme inhibition. The most significant efforts in designing 17β-HSD1 inhibitors in decades have progressed through structure activity relationship studies supported by the availability of both small and protein molecule structures, with the elimination of residual estrogenic activity in the inhibitors. The first non-estrogenic inhibitors of 17β-HSD1 to show activity in vivo (breast cancer animal model) are now reported.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords 17beta-hydroxysteroid dehydrogenase (17beta-HSD) superfamily; Estrogen-dependent breast cancer; Pre-receptor modulation of steroid hormone action; Rational design of inhibitors; Structure-activity relationship; Protease Cleavage Sites ; Dependent Breast-cancer ; Aldo-keto Reductases ; 17beta-hydroxysteroid Dehydrogenase ; Hydroxysteroid Dehydrogenases ; Retinol Dehydrogenase ; Critical Residues ; Human Placenta ; Drug Design ; Web-server
ISSN (print) / ISBN 1568-0266
e-ISSN 1873-4294
Journal Current Topics in Medicinal Chemistry
Quellenangaben Volume: 13, Issue: 10, Pages: 1164-1171 Article Number: , Supplement: ,
Publisher Bentham Science Publishers
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Experimental Genetics (IEG)