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Glatz, J.* ; Varga, J.* ; Garcia-Allende, P. ; Koch, M. ; Greten, F.R.* ; Ntziachristos, V.

Concurrent video-rate color and near-infrared fluorescence laparoscopy.

J. Biomed. Opt. 18:101302 (2013)
Publ. Version/Full Text Volltext DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The visual identification and demarcation of tumors and tumor margins remains challenging due to the low optical contrast of cancer cells over surrounding tissues. Fluorescence molecular imaging was recently considered clinically for improving cancer detection during open surgery. We present herein a next step in the development of fluorescence molecular guidance by describing a novel video-rate imaging laparoscope capable of concurrently recording color and near-infrared fluorescence images and video. Video-rate operation is based on graphics processing unit-based image processing. We examine the optical characteristics of the system developed and provide performance metrics related to intra-operative endoscopic guidance, showcased on phantoms and endoscopic color and fluorescence molecular imaging of tumors in a mouse model of the human disease.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords cancer; laparoscopy; endoscopy; near-infrared imaging; optical imaging; intraoperative imaging; fluorescence imaging; Mouse Models ; Cancer ; Colonoscopy ; Inflammation ; Tumors ; Diagnosis ; Oncology ; Polyp ; Gene ; Mice
ISSN (print) / ISBN 1083-3668
e-ISSN 1560-2281
Journal Journal of Biomedical Optics
Quellenangaben Volume: 18, Issue: 10, Pages: , Article Number: 101302 Supplement: ,
Publisher SPIE
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)