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Marzi, C. ; Huth, C. ; Herder, C.* ; Baumert, J.J. ; Thorand, B. ; Rathmann, W.* ; Meisinger, C. ; Wichmann, H.-E. ; Roden, M.* ; Peters, A. ; Grallert, H. ; Koenig, W.* ; Illig, T.

Acute-phase serum amyloid A protein and its implication in the development of type 2 diabetes in the KORA S4/F4 study.

Diabetes Care 36, 1321-1326 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVE We sought to investigate whether elevated levels of acute-phase serum amyloid A (A-SAA) protein precede the onset of type 2 diabetes independently of other risk factors, including parameters of glucose metabolism. RESEARCH DESIGN AND METHODS Within the population-based Cooperative Health Research in the Region of Augsburg (KORA) S4 study, we measured A-SAA concentrations in 836 initially nondiabetic subjects (55-74 years of age) without clinically overt inflammation who participated in a 7-year follow-up examination including an oral glucose tolerance test. RESULTS A-SAA concentrations were significantly associated with incident type 2 diabetes (odds ratio [OR] for a one-SD increase of A-SAA adjusted for age and sex = 1.28 [95% CI 1.08-1.53], P = 0.005), particularly in younger subjects (P value for interaction = 0.047). The association attenuated when adjusting for parameters of glucose metabolism (fasting glucose, fasting insulin, HbA1c, and 2-h glucose; OR 1.16 [0.95-1.42], P = 0.15). Similar analyses for high-sensitive C-reactive protein (hs-CRP) yielded the following ORs: 1.39 (1.10-1.68, P = 0.0006) and 1.13 (0.88-1.45, P = 0.34), respectively. In contrast, A-SAA concentrations were significantly associated with 2-h glucose levels at follow-up even after adjustment for parameters of glucose metabolism (P = 0.008, n = 803). CONCLUSIONS Our findings indicate similarly strong prospective associations with type 2 diabetes for A-SAA and hs-CRP and suggest a potential causal link via postchallenge hyperglycemia.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Impaired Glucose-tolerance ; Bioelectrical-impedance Analysis ; Sex-differences ; Adipose-tissue ; Association ; Interleukin-6 ; Inflammation ; Population ; Expression ; Prediction
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 36, Issue: 5, Pages: 1321-1326 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
German Center for Diabetes Reseach (DZD)