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Genome-wide association analysis identifies loci for left-sided displacement of the abomasum in German Holstein cattle.
J. Dairy Sci. 96, 3959-3964 (2013)
Left-sided displacement of the abomasum (LDA) is one of the most common disorders of the digestive system in many dairy breeds and particularly in Holstein dairy cows. We performed a genome-wide association study for 854 German Holstein cows, including 225 cases and 629 controls. All cows were genotyped using the Illumina Bovine SNP50 Bead Chip (Illumina Inc., San Diego, CA). After quality control of genotypes, a total of 36,226 informative single nucleotide polymorphisms (SNP) were left for analysis. We used a mixed linear model approach for a genome-wide association study of LDA. In total, 36 SNP located on 17 bovine (Bos taurus) chromosomes (BTA) showed associations with LDA at nominal -log(10) P-values >3.0. Two of these SNP, located on BTA11 at 46.70 Mb and BTA20 at 16.67 Mb, showed genome-wide significant associations with LDA at -log(10) P-values >4.6. Pathway analyses indicated genes involved in calcium metabolism and insulin-dependent diabetes mellitus to be factors in the pathogenesis of LDA in German Holstein cows.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Left-sided Displacement Of The Abomasum ; Genome-wide Association Study ; Insulin ; Calcium; Dairy-cows ; Motility Disorders ; Complex Traits ; Dilatation ; Volvulus
ISSN (print) / ISBN
0022-0302
e-ISSN
1525-3198
Journal
Journal of Dairy Science
Quellenangaben
Volume: 96,
Issue: 6,
Pages: 3959-3964
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)