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Open Access Green as soon as Postprint is submitted to ZB.
Simulation of light ion induced DNA damage patterns.
Radiat. Prot. Dosim. 122, 116-120 (2006)
The biophysical simulation code PARTRAC was extended by a module to handle ions heavier than alpha particles. Cross sections for ion–electron interactions were taken from He++ ions of the same velocity and scaled by Zeff2/4. Calculated linear energy transfer values, radial dose distributions and secondary electron spectra were found in agreement with experimental results. DNA damage due to irradiation of human fibroblast cells by several light ions from H to S was calculated for various energies complemented by 220 kVp X rays as reference radiation. With increasing linear energy transfer, the calculated total yield of double-strand breaks per dose showed saturation behaviour at about twice the value for reference radiation. When data analysis methods for experimental double-strand break yield determination were applied to the simulated DNA damage patterns, the two data sets were found in accord. The calculated patterns of DNA damage clusters were analysed on local and regional scale finding regional clusters in closer correlation to experimental cell inactivation data.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2006
HGF-reported in Year
0
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Journal
Radiation Protection Dosimetry
Quellenangaben
Volume: 122,
Pages: 116-120
Publisher
Oxford University Press
Publishing Place
Oxford
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Protection (ISS)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Radiation Sciences
PSP Element(s)
G-501100-004
Erfassungsdatum
2007-08-02