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Schneider, F.* ; Hoster, E.* ; Unterhalt, M.* ; Schneider, S.* ; Dufour, A.* ; Benthaus, T.* ; Mellert, G.* ; Zellmeier, E.* ; Bohlander, S.K. ; Feuring-Buske, M. ; Buske, C. ; Braess, J.* ; Fritsch, S.* ; Heinecke, A.* ; Sauerland, M.C.* ; Berdel, W.E.* ; Buechner, T.* ; Woermann, B.J.* ; Hiddemann, W. ; Spiekermann, K.

NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS).

Blood 113, 5250-5253 (2009)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Mutations in the NPM1 gene represent the most frequent genetic alterations in patients with acute myeloid leukemia (AML) and are associated with a favorable outcome. In 690 normal karyotype (NK) AML patients the complete remission rates (CRs) and the percentage of patients with adequate in vivo blast cell reduction 1 week after the end of the first induction cycle were significantly higher in NPM1(+) (75% and 80%, respectively) than in NPM1(-) (57% and 57%, respectively) patients, but were unaffected by the FLT3-ITD status. Multivariate analyses revealed the presence of a NPM1 mutation as an independent positive prognostic factor for the achievement of an adequate day-16 blast clearance and a CR. In conclusion, NPM1(+) blast cells show a high in vivo sensitivity toward induction chemotherapy irrespective of the FLT3-ITD mutation status. These findings provide insight into the pathophysiology and help to understand the favorable clinical outcome of patients with NPM1(+) AML.
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Publication type Article: Journal article
Document type Scientific Article
Keywords acute myeloid-leukemia; acute myelogenous leukemia; younger adults; prognostic relevance; favorable prognosis; normal cytogenetics; nucleophosmin npm1; induction therapy; gene-mutations; kappa-b
Language english
Publication Year 2009
HGF-reported in Year 2009
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Journal Blood
Quellenangaben Volume: 113, Issue: 21, Pages: 5250-5253 Article Number: , Supplement: ,
Publisher American Society of Hematology
Reviewing status Peer reviewed
Institute(s) CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-521000-001
DOI 10.1182/blood-2008-09-172668
Scopus ID 67149084950
Erfassungsdatum 2009-12-31
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