PuSH - Publication Server of Helmholtz Zentrum München: Caesium accumulation in yeast and plants is selectively repressed by loss of the SNARE Sec22p/SEC22.

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Dräxl, S. ; Müller, J. ; Li, W.B. ; Michalke, B. ; Scherb, H. ; Hense, B.A. ; Tschiersch, J. ; Kanter, U. ; Schäffner, A.

Caesium accumulation in yeast and plants is selectively repressed by loss of the SNARE Sec22p/SEC22.

Nat. Commun. 4:2092 (2013)

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The non-essential cation caesium (Cs⁺) is assimilated by all organisms. Thus, anthropogenically released radiocaesium is of concern to agriculture. Cs⁺ accumulates owing to its chemical similarity to the potassium ion (K⁺). The apparent lack of a Cs⁺-specific uptake mechanism has obstructed attempts to manipulate Cs⁺ accumulation without causing pleiotropic effects. Here we show that the SNARE protein Sec22p/SEC22 specifically impacts Cs⁺ accumulation in yeast and in plants. Loss of Saccharomyces cerevisiae Sec22p does not affect K⁺ homeostasis, yet halves Cs⁺ concentration compared with the wild type. Mathematical modelling of the uptake time course predicts a compromised vacuolar Cs⁺ deposition in sec22Δ. Biochemical fractionation confirms this and indicates a new feature of Sec22p in enhancing non-selective cation deposition. A developmentally controlled loss-of-function mutant of the orthologous Arabidopsis thaliana SEC22 phenocopies the reduced Cs⁺ uptake without affecting plant growth. This finding provides a new strategy to reduce radiocaesium entry into the food chain.

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