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Takeuchi, J.K.* ; Lickert, H. ; Bisgrove, B.W.* ; Sun, X.* ; Yamamoto, M.* ; Chawengsaksophak, K.* ; Hamada, H.* ; Yost, H.J.* ; Rossant, J.* ; Bruneau, BG.*

Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.

Proc. Natl. Acad. Sci. U.S.A. 104, 846-851 (2007)
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Notch-mediated induction of Nodal at the vertebrate node is a critical step in initiating left-right (LR) asymmetry. In mice and zebrafish we show that Baf60c, a subunit of the Swi/Snf-like BAF chromatin remodeling complex, is essential for establishment of LR asymmetry. Baf60c knockdown mouse embryos fail to activate Nodal at the node and also have abnormal node morphology with mixing of crown and pit cells. In cell culture, Baf60c is required for Notch-dependent transcriptional activation and functions to stabilize interactions between activated Notch and its DNA-binding partner, RBP-J. Brg1 is also required for these processes, suggesting that BAF complexes are key components of nuclear Notch signaling. We propose a critical role for Baf60c in Notch-dependent transcription and LR asymmetry.
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Publication type Article: Journal article
Document type Scientific Article
Keywords chromatin; Swi/Snf; node; CHROMATIN-REMODELING COMPLEX; MOUSE EMBRYO; ZEBRAFISH EMBRYO; NODAL EXPRESSION; CELL FATE; HEART; AXIS; CARDIOMYOGENESIS; TRANSACTIVATION; RECEPTORS
Language english
Publication Year 2007
HGF-reported in Year 2007
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Journal Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Volume: 104, Issue: 3, Pages: 846-851 Article Number: , Supplement: ,
Publisher National Academy of Sciences
Reviewing status Peer reviewed
Institute(s) Institute of Stem Cell Research (ISF)
PSP Element(s) G-550100-001
PubMed ID 17210915
DOI 10.1073/pnas.0608118104
WOS ID 000243761100031
Scopus ID 33846465548
Erfassungsdatum 2007-11-06
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