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The CD14+ CD16+ blood monocytes: Their role in infection and inflammation.
J. Leukoc. Biol. 81, 584-592 (2007)
Publ. Version/Full Text
DOI
PMC
Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16- and the CD14+ CD16+ monocytes. These cells have been shown to exhibit distinct phenotype and function, and the CD14+ CD16+ were labeled proinflammatory based on higher expression of proinflammatory cytokines and higher potency in antigen presentation. The current review describes these properties, including the relationship to dendritic cells, and summarizes the host of publications about CD14+ CD16+ monocytes in inflammation and infectious disease in man, all of which suggest a crucial role of these cells in the disease processes. The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
cytokines; migration; HIV; arthritis; atherosclerosis
ISSN (print) / ISBN
0741-5400
e-ISSN
1938-3673
Journal
Journal of Leukocyte Biology
Quellenangaben
Volume: 81,
Issue: 3,
Pages: 584-592
Publisher
FASEB
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)