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Breitfeld, J.* ; Tönjes, A.* ; Böttcher, Y.* ; Schleinitz, D.* ; Wiele, N.* ; Marzi, C. ; Brockhaus, C. ; Rathmann, W.* ; Huth, C. ; Grallert, H. ; Illig, T. ; Blüher, M.* ; Kovacs, P.* ; Stumvoll, M.*

Genetic variation in the vaspin gene affects circulating serum vaspin concentrations.

Int. J. Obes. 37, 861-866 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Objective:Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipokine potentially linking obesity, insulin resistance and type 2 diabetes. Here, we searched for genetic determinants that could explain the variability in serum vaspin concentrations.Research Design and Methods:First, we conducted a genome-wide association study (GWAS) for serum vaspin in the Sorbs cohort (N=826). Subsequently, 26 single-nucleotide polymorphisms (SNPs) covering genetic variation in the vaspin locus were genotyped in the Sorbs. In addition, we measured serum vaspin concentrations in 1806 samples from Augsburg/the Cooperative Health Research in the Region of Augsburg (KORA) for replication of the association signals. Finally, we conducted association analyses of vaspin SNPs with metabolic traits in the Sorbs (N=1013), KORA (N=1813) and a further cohort from Germany (Leipzig: N=1857).Results:Six SNPs mapping between serpinA1 and serpinA4, including the vaspin locus, on chromosome 14 reached P-values 10(-8) in the GWAS in the Sorbs. The fine mapping of variants within the vaspin locus in the Sorbs and subsequent replication in the KORA sample revealed several SNPs significantly associated with serum vaspin concentrations reaching P-values of up to 10(-35). However, no significant association with type 2 diabetes or related traits was found in either cohort after the Bonferroni correction for multiple comparisons.Conclusion:Our data show that the variability in serum vaspin concentrations might be explained by its genetic variants.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Vaspin ; Insulin Resistance ; Serum Vaspin Concentrations ; Gwas; Serine-protease Inhibitor ; Self-contained Population ; Genome-wide Association ; Adipose-tissue ; Glucose ; Obesity ; Expression ; Variants ; Sorbs ; Adipocytokine
ISSN (print) / ISBN 0307-0565
e-ISSN 1476-5497
Journal International Journal of Obesity
Quellenangaben Volume: 37, Issue: 6, Pages: 861-866 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Molecular Epidemiology (AME)
Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)