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Benjamin, E.J.* ; Rice, K.M.* ; Arking, D.E.* ; Pfeufer, A. ; van Noord, C.* ; Smith, A.V.* ; Schnabel, R.B.* ; Bis, J.C.* ; Boerwinkle, E.* ; Sinner, M.F.* ; Dehghan, A.* ; Lubitz, S.A.* ; D'Agostino, R.B.* ; Lumley, T.* ; Ehret, G.B.* ; Heeringa, J.* ; Aspelund, T.* ; Newton-Cheh, C.* ; Larson, M.G.* ; Marciante, K.D.* ; Soliman, E.Z.* ; Rivadeneira, F.* ; Wang, T.J.* ; Eiriksdottir, G.* ; Levy, D.* ; Psaty, B.M.* ; Li, M.* ; Chamberlain, A.M.* ; Hofman, A.* ; Vasan, R.S.* ; Harris, T.B.* ; Rotter, J.I.* ; Kao, W.H.L.* ; Agarwal, S.K.* ; Stricker, B.H.C.* ; Wang, K.* ; Launer, L.J.* ; Smith, N.L.* ; Chakravarti, A.* ; Uitterlinden, A.G.* ; Wolf, P.A.* ; Sotoodehnia, N.* ; Köttgen, A.* ; van Duijn, C.M.* ; Meitinger, T. ; Mueller, M. ; Perz, S. ; Steinbeck, G.* ; Wichmann, H.-E. ; Lunetta, K.L.* ; Heckbert, S.R.* ; Gudnason, V.* ; Alonso, A.* ; Kääb, S.* ; Ellinor, P.T.* ; Witteman, J.C.*

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.

Nat. Genet. 41, 879-81 (2009)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).
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Publication type Article: Journal article
Document type Scientific Article
Keywords transcription factor atbf1; lifetime risk; differentiation; prevalence
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 41, Issue: 8, Pages: 879-81 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
Institute of Biological and Medical Imaging (IBMI)