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Open Access Green as soon as Postprint is submitted to ZB.
Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.
Genesis 46, 530-536 (2008)
Taking advantage of a mutant estrogen receptor ligand binding domain (ER(T2)), we developed novel Caspase fusion proteins for inducible apoptosis. We show that Caspase-ER(T2) fusion proteins become specifically activated by the synthetic ligand 4-OH- tamoxifen and rapidly induce apoptotic cell death in human, murine, and zebrafish cells. This novel tool for targeted cell ablation greatly facilitates the generation of disease models as well as developmental and regeneration studies in model organisms.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
caspase; apoptosis; tamoxifen; cell ablation; estrogen receptor
ISSN (print) / ISBN
1526-954X
e-ISSN
1526-968X
Quellenangaben
Volume: 46,
Issue: 10,
Pages: 530-536
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)