PuSH - Publication Server of Helmholtz Zentrum München

Bønnelykke, K.* ; Matheson, M.C.* ; Pers, T.H.* ; Granell, R.* ; Strachan, D.P.* ; Alves, A.C.* ; Linneberg, A.* ; Curtin, J.A.* ; Warrington, N.M.* ; Standl, M. ; Kerkhof, M.* ; Jonsdottir, I.* ; Bukvic, B.K.* ; Kaakinen, M.* ; Sleimann, P.* ; Thorleifsson, G.* ; Thorsteinsdottir, U.* ; Schramm, K. ; Baltic, S.* ; Kreiner-Møller, E.* ; Simpson, A.* ; Pourcain, B.S.* ; Coin, L.* ; Hui, J.* ; Walters, E.H.* ; Tiesler, C.M. ; Duffy, D.L.* ; Jones, G.* ; Australian Asthma Genetics Consortium (AAGC) (*) ; Ring, S.M.* ; McArdle, W.L.* ; Price, L.* ; Robertson, C.F.* ; Pekkanen, J.* ; Tang, C.S.* ; Thiering, E. ; Montgomery, G.W.* ; Hartikainen, A.L.* ; Dharmage, S.C.* ; Husemoen, L.L.* ; Herder, C.* ; Kemp, J.P.* ; Elliot, P.* ; James, A.* ; Waldenberger, M. ; Abramson, M.J.* ; Fairfax, B.P.* ; Knight, J.C.* ; Gupta, R.* ; Thompson, P.J.* ; Holt, P.* ; Sly, P.* ; Hirschhorn, J.N.* ; Blekic, M.* ; Weidinger, S.* ; Hakonarsson, H.* ; Stefansson, K.* ; Heinrich, J. ; Postma, D.S.* ; Custovic, A.* ; Pennell, C.E.* ; Jarvelin, M.R.* ; Koppelman, G.H.* ; Timpson, N.* ; Ferreira, M.A.* ; Bisgaard, H.* ; EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (*) ; Henderson, A.J.*

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.

Nat. Genet. 45, 902-906 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Susceptibility Loci ; Gene-expression ; Crohns-disease ; Risk Loci ; Asthma ; Variants ; Atopy ; Mechanisms ; Micrornas ; Number
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 45, Issue: 8, Pages: 902-906 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Research Unit Molecular Epidemiology (AME)