PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Bønnelykke, K.* ; Matheson, M.C.* ; Pers, T.H.* ; Granell, R.* ; Strachan, D.P.* ; Alves, A.C.* ; Linneberg, A.* ; Curtin, J.A.* ; Warrington, N.M.* ; Standl, M. ; Kerkhof, M.* ; Jonsdottir, I.* ; Bukvic, B.K.* ; Kaakinen, M.* ; Sleimann, P.* ; Thorleifsson, G.* ; Thorsteinsdottir, U.* ; Schramm, K. ; Baltic, S.* ; Kreiner-Møller, E.* ; Simpson, A.* ; Pourcain, B.S.* ; Coin, L.* ; Hui, J.* ; Walters, E.H.* ; Tiesler, C.M. ; Duffy, D.L.* ; Jones, G.* ; Australian Asthma Genetics Consortium (AAGC) (*) ; Ring, S.M.* ; McArdle, W.L.* ; Price, L.* ; Robertson, C.F.* ; Pekkanen, J.* ; Tang, C.S.* ; Thiering, E. ; Montgomery, G.W.* ; Hartikainen, A.L.* ; Dharmage, S.C.* ; Husemoen, L.L.* ; Herder, C.* ; Kemp, J.P.* ; Elliot, P.* ; James, A.* ; Waldenberger, M. ; Abramson, M.J.* ; Fairfax, B.P.* ; Knight, J.C.* ; Gupta, R.* ; Thompson, P.J.* ; Holt, P.* ; Sly, P.* ; Hirschhorn, J.N.* ; Blekic, M.* ; Weidinger, S.* ; Hakonarsson, H.* ; Stefansson, K.* ; Heinrich, J. ; Postma, D.S.* ; Custovic, A.* ; Pennell, C.E.* ; Jarvelin, M.R.* ; Koppelman, G.H.* ; Timpson, N.* ; Ferreira, M.A.* ; Bisgaard, H.* ; EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (*) ; Henderson, A.J.*

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.

Nat. Genet. 45, 902-906 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
35.209
7.147
165
179
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Susceptibility Loci ; Gene-expression ; Crohns-disease ; Risk Loci ; Asthma ; Variants ; Atopy ; Mechanisms ; Micrornas ; Number
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 45, Issue: 8, Pages: 902-906 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Research Unit Molecular Epidemiology (AME)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-001
G-500700-001
G-504200-001
PubMed ID 23817571
DOI 10.1038/ng.2694
WOS ID WOS:000322374900013
Scopus ID 84881030765
Erfassungsdatum 2013-07-08
[➜Report correction]