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Open Access Green as soon as Postprint is submitted to ZB.
Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling.
Nat. Cell Biol. 15, 602-613 (2013)
The adult mouse subependymal zone (SEZ) harbours adult neural stem cells (aNSCs) that give rise to neuronal and oligodendroglial progeny. However it is not known whether the same aNSC can give rise to neuronal and oligodendroglial progeny or whether these distinct progenies constitute entirely separate lineages. Continuous live imaging and single-cell tracking of aNSCs and their progeny isolated from the mouse SEZ revealed that aNSCs exclusively generate oligodendroglia or neurons, but never both within a single lineage. Moreover, activation of canonical Wnt signalling selectively stimulated proliferation within the oligodendrogliogenic lineage, resulting in a massive increase in oligodendrogliogenesis without changing lineage choice or proliferation within neurogenic clones. In vivo activation or inhibition of canonical Wnt signalling respectively increased or decreased the number of Olig2 and PDGFR-alpha positive cells, suggesting that this pathway contributes to the fine tuning of oligodendrogliogenesis in the adult SEZ.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Mouse Cerebral-cortex ; Subventricular Zone ; Olfactory-bulb ; Oligodendrocyte Lineage ; Neuronal Precursors ; Progenitor Cells ; Mammalian Brain ; Glial-cells ; In-vitro ; Expression
ISSN (print) / ISBN
1465-7392
e-ISSN
1476-4679
Journal
Nature Cell Biology
Quellenangaben
Volume: 15,
Issue: 6,
Pages: 602-613
Publisher
Nature Publishing Group
Non-patent literature
Publications
Reviewing status
Peer reviewed