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Open Access Green as soon as Postprint is submitted to ZB.
ORMDL3 - guilt by association?
Clin. Exp. Allergy 38, 1579-1581 (2008)
A recent British-German study described ORMDL3 as a new asthma gene. Although the association with chromosome 17q 12 marker is plausible from earlier linkage data, it is far from being clear which gene caused the association signal, as it is derived from a large linkage disequilibrium (LD) block. Not only Aiolos and GSDML but also distant genes that are regulated by this site may be relevant. There may be even unidentified RNA transcripts requiring a much more detailed genetic and functional analysis before finding ORMDL3 guilty by association.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
allergy; asthma; gene; linkage disequilibrium; ORMDL3
ISSN (print) / ISBN
0954-7894
e-ISSN
1365-2222
Journal
Clinical & Experimental Allergy
Quellenangaben
Volume: 38,
Issue: 10,
Pages: 1579-1581
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)