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Kuhn, T.* ; Kaaks, R.* ; Becker, S.* ; Eomois, P.P.* ; Clavel-Chapelon, F.* ; Kvaskoff, M.* ; Dossus, L.* ; Tjønneland, A.* ; Olsen, A.* ; Overvad, K.* ; Chang-Claude, J.* ; Lukanova, A.* ; Buijsse, B.* ; Boeing, H.* ; Trichopoulou, A.* ; Lagiou, P.* ; Bamia, C.* ; Masala, G.* ; Krogh, V.* ; Sacerdote, C.* ; Tumino, R.* ; Mattiello, A.* ; Buckland, G.* ; Sánchez, M.J.* ; Menéndez, V.* ; Chirlaque, M.D.* ; Barricarte, A.* ; Bueno-de-Mesquita, H.B.* ; van Duijnhoven, F.J.* ; van Gils, C.H.* ; Bakker, M.F.* ; Weiderpass, E.* ; Skeie, G.* ; Brustad, M.* ; Andersson, A.* ; Sund, M.* ; Wareham, N.J.* ; Khaw, K.T.* ; Travis, R.C.* ; Schmidt, J.A.* ; Rinaldi, S.* ; Romieu, I.* ; Gallo, V.* ; Murphy, N.* ; Riboli, E.* ; Linseisen, J.

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition: A nested case-control study.

Int. J. Cancer 133, 1689-1700 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. Although the results of case-control studies indicate that circulating 25-hydroxyvitamin D [25(OH)D] is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case-control study embedded in the European Prospective Investigation into Cancer and Nutrition (EPIC) was carried out comprising 1,391 incident breast cancer cases and 1,391 controls. Multivariable conditional logistic regression models did not reveal a significant overall association between season-standardized 25(OH)D levels and the risk of breast cancer (ORQ4-Q1 [95% CI]: 1.07 [0.85-1.36], ptrend = 0.67). Moreover, 25(OH)D levels were not related to the risks of estrogen receptor positive tumors (ORQ4-Q1 [95% CI]: 0.97 [0.67-1.38], ptrend = 0.90) and estrogen receptor negative tumors (ORQ4-Q1 [95% CI]: 0.97 [0.66-1.42], ptrend = 0.98). In hormone replacement therapy (HRT) users, 25(OH)D was significantly inversely associated with incident breast cancer (ORlog2 [95% CI]: 0.62 [0.42-0.90], p = 0.01), whereas no significant association was found in HRT nonusers (ORlog2 [95% CI]: 1.14 [0.80-1.62], p = 0.48). Further, a nonsignificant inverse association was found in women with body mass indices (BMI) < 25 kg/m(2) (ORlog2 [95% CI]: 0.83 [0.67-1.03], p = 0.09), as opposed to a borderline significant positive association in women with BMI ≥ 25 kg/m(2) (ORlog2 [95% CI]: 1.30 [1.0-1.69], p = 0.05). Overall, prediagnostic levels of circulating 25(OH)D were not related to the risk of breast cancer in the EPIC study. This result is in line with findings in the majority of prospective studies and does not support a role of vitamin D in the development of breast cancer.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords 25-hydroxyvitamin D; breast cancer; estrogen receptor status; prospective study; vitamin D; D-binding Protein ; Circulating Vitamin-d ; French E3n Cohort ; Postmenopausal Women ; Nurses Health ; Serum-levels ; Association ; Prevention ; Calcium ; Time
ISSN (print) / ISBN 0020-7136
e-ISSN 1097-0215
Journal International Journal of Cancer
Quellenangaben Volume: 133, Issue: 7, Pages: 1689-1700 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)