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Open Access Green as soon as Postprint is submitted to ZB.
EUCOMM the European conditional mouse mutagenesis program.
Brief. Funct. Genomic. Proteomic. 6, 180-185 (2007)
Functional analysis of the mammalian genome is an enormous challenge for biomedical scientists. To facilitate this endeavour, the European Conditional Mouse Mutagenesis Program (EUCOMM) aims at generating up to 12 000 mutations by gene trapping and up to 8000 mutations by gene targeting in mouse embryonic stem (ES) cells. These mutations can be rendered into conditional alleles, allowing Cre recombinase-mediated disruption of gene function in a time- and tissue-specific manner. Furthermore, the EUCOMM program will generate up to 320 mouse lines from the EUCOMM resource and up to 20 new Cre driver mouse lines. The EUCOMM resource of vectors, mutant ES cell lines and mutant mice will be openly available to the scientific community. EUCOMM will be one of the cornerstones of an international effort to create a global mouse mutant resource.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
mouse mutagenesis; gene trap; gene targeting; conditional allele
ISSN (print) / ISBN
1473-9550
e-ISSN
1477-4062
Journal
Briefings in Functional Genomics
Quellenangaben
Volume: 6,
Issue: 3,
Pages: 180-185
Publisher
Oxford University Press
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)