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Heimbeck, I. ; Wjst, M. ; Apfelbacher, C.J.*

Low vitamin D serum level is inversely associated with eczema in children and adolescents in Germany.

Allergy 68, 906-910 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: Recent studies have yielded heterogeneous results regarding the relationship between vitamin D and atopic conditions. The aim of this study was to investigate the association between serum vitamin D level and the prevalence of eczema in German children and adolescents. METHODS: Data were drawn for children aged 1-17 from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), a nationwide cross-sectional representative survey. 25-hydroxyvitamin D (25(OH)D) serum concentration was measured in 9838 individuals with eczema and categorized into quartiles. We investigated the association of vitamin D level and eczema by means of logistic regression models. RESULTS: Weighted prevalence of eczema was 13.5% (95% confidence interval (CI) 12.6-14.4%). Mean vitamin D level was significantly higher in those with eczema compared with those without (P < 0.0001). Logistic regression revealed an inverse association between low levels of vitamin D and eczema (multivariate OR for quartile 1 vs quartile 2: 0.76 (95% CI 0.61-0.94)). CONCLUSIONS: This study suggests that low serum vitamin D level is inversely associated with eczema in German children and adolescents. Prospective studies are required to confirm this result, to discuss a potential opportunity for prevention of eczema.
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Publication type Article: Journal article
Document type Scientific Article
Keywords atopy; eczema; epidemiology; vitamin D; Atopic-dermatitis ; Health Interview ; 25-hydroxyvitamin D ; D Deficiency ; Kiggs ; Prevalence ; Allergy ; Diseases
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 68, Issue: 7, Pages: 906-910 Article Number: , Supplement: ,
Publisher Wiley
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)