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Open Access Green as soon as Postprint is submitted to ZB.
Epstein-Barr virus and host cell methylation: Regulation of latency, replication and virus reactivation.
Curr. Opin. Virol. 3, 260-265 (2013)
Epigenetic mechanisms govern the different life phases of Epstein-Barr virus (EBV). In the first prelatent phase the viral DNA acquires nucleosomes, histone marks are established, and 5'-methyl cytosine residues become detectable. In the latent phase repressive histone marks and extensive DNA methylation silence the majority of viral promoters sparing a few latent genes. DNA methylation is a prerequisite for the induction of EBV's lytic phase in order to escape from latency and give rise to viral progeny. All three phases rely on the different epigenetic states of viral DNA and the availability of viral and cellular factors. EBV exploits cellular mechanisms of epigenetic regulation for its different life phases and serves as a marvelous example of an intimate host-pathogen relationship.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
B-lymphocytes ; Down-regulation ; Gene Promoter ; Viral Genome ; Infection ; Switch ; Lines ; Bzlf1
ISSN (print) / ISBN
1879-6257
e-ISSN
1879-6265
Journal
Current Opinion in Virology
Quellenangaben
Volume: 3,
Issue: 3,
Pages: 260-265
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Gene Vector (AGV)