Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Radiation treatment effects on the proteome of the tumour microenvironment.
Adv. Exp. Med. Biol. 990, 49-60 (2013)
Exposure of tumourous tissue to ionizing radiation initiates a wound-healing response involving remodelling of the extracellular microenvironment. The initial reaction involves direct damage to the matrix proteins and the secretion and activation of proteolytic enzymes that lead to local destruction of the extracellular matrix. Subsequently the wounded area may undergo complete repair, may enter a prolonged period of heightened proteolysis, or may overproduce matrix proteins leading to fibrosis. The source of matrix degrading enzymatic activity may be the tumour cells and the tumour stroma. Additional complexity is provided by proteolytic activity released from tissue macrophages, mast cells and by invading inflammatory cells. The local production of growth factors, including VEGF and TGF-β play a key role in coordinating the response. It is anticipated that the application of modern proteomic technologies will reveal hitherto unrecognised levels of complexity in these processes. Hopefully this will lead to the development of new therapeutic strategies to prevent long-term health implications of radiation exposure.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Bystander Effect ; Cytokine ; Ecm ; Extracellular Matrix ; Hypoxia ; Inflammation ; Ionizing Radiation ; Lysis ; Metastasis ; Proteolysis ; Radiation Injury ; Signaling Pathways ; Stroma ; Tumour Microenvironment; Induced Lung Injury; Cell Matrix Interactions; Collagen Type-iv; Ionizing-radiation; Extracellular-matrix; In-vitro; Gene-expression; X-irradiation; Mesenchymal Transition; Radiogenic Destruction
ISSN (print) / ISBN
0065-2598
Quellenangaben
Volume: 990,
Pages: 49-60
Publisher
Springer
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Biology (ISB)