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Bousquet, J.* ; Antò, J.M.* ; Heinrich, J. ; Keil, T.* ; Postma, D.S.* ; Sunyer, J.*

Correspondence on the paper by Krauss-Etschmann S, Bush A, Bellusci S, et al.

Thorax 68, 964:964 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Rationale Rationale Information about daily physical activity levels (PAL) in subjects with undiagnosed chronic obstructive pulmonary disease (COPD) is scarce. This study aims to assess PA and to investigate the associations between PA and clinical characteristics in subjects with newly diagnosed COPD. Methods Methods Fifty-nine subjects with a new spirometry-based diagnosis of mild (n=38) and moderate (n=21) COPD (63 +/- 6 years, 68% male) were matched with 65 smoking controls (62 +/- 7 years, 75% male). PA (daily steps, time spent in moderate-to-vigorous intense physical activities (MVPA) and PAL) was measured by accelerometry. Dyspnoea, complete pulmonary function tests, peripheral muscle strength and exercise capacity served as clinical characteristics. Results Results PA was significantly lower in COPD versus smoking controls (7986 +/- 2648 vs 9765 +/- 3078 steps, 64 (27-120) vs 110 (55-164) min of MVPA, 1.49 +/- 0.21 vs 1.62 +/- 0.24 PAL respectively, all p < 0.05). Subjects with COPD with either mild symptoms of dyspnoea (mMRC 1), those with lower diffusion capacity (T-L,co), low 6 min walking distance (6MWD) or low maximal oxygen uptake (VO2 peak) had significantly lower PA. Multiple regression analysis identified 6 MWD and T-L,co as independent predictors of PA in COPD. Conclusions Conclusions The reduction in PA starts early in the disease, even when subjects are not yet diagnosed with COPD. Inactivity is more pronounced in subjects with mild symptoms of dyspnoea, lower levels of diffusion capacity and exercise capacity.
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Publication type Article: Journal article
Document type Letter to the Editor
Corresponding Author
Keywords Community-acquired Pneumonia ; Population-based Cohort ; Nested Case-control ; Survival Analysis ; Risk-factors ; Benzodiazepines ; Mortality ; Impact
ISSN (print) / ISBN 0040-6376
e-ISSN 1468-3296
Journal Thorax
Quellenangaben Volume: 68, Issue: 10, Pages: 964 Article Number: 964 Supplement: ,
Publisher BMJ Publishing Group
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)