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Open Access Green as soon as Postprint is submitted to ZB.
Cationic thermosensitive liposomes: A novel dual targeted heat-triggered drug delivery approach for endothelial and tumor cells.
Nano Lett. 13, 2324-2331 (2013)
Developing selectively targeted and heat-responsive nanocarriers holds paramount promises in chemotherapy. We show that this can be achieved by designing liposomes combining cationic charged and thermosensitive lipids in the bilayer. We demonstrated, using flow cytometry, live cell imaging, and intravital optical imaging, that cationic thermosensitive liposomes specifically target angiogenic endothelial and tumor cells. Application of mild hyperthermia led to a rapid content release extra- and intracellularly in two crucial cell types in a solid tumor.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cationic Thermosensitive Liposomes; Hyperthermia; Triggered Release; Drug Delivery; Targeted Nanomedicine; Anionic Phospholipids ; Vascular-permeability ; Content Release ; Solid Tumors ; In-vitro ; Doxorubicin ; Hyperthermia ; Trial ; Anthracyclines ; Therapeutics
ISSN (print) / ISBN
1530-6984
e-ISSN
1530-6992
Journal
Nano Letters
Quellenangaben
Volume: 13,
Issue: 6,
Pages: 2324-2331
Publisher
American Chemical Society (ACS)
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)