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Risk assessment of released cellulose nanocrystals-mimicking inhalatory exposure.
J. Phys. Conf. Ser. 429, IOP:012008 (2013)
Publ. Version/Full Text Volltext
DOI
Cellulose nanocrystals (CNCs) exhibit advantageous chemical and mechanical properties that render them attractive for a wide range of applications. During the life-cycle of CNC containing materials the nanocrystals could be released and become airborne, posing a potential inhalatory exposure risk towards humans. Absent reliable and dose-controlled models that mimic this exposure in situ is a central issue in gaining an insight into the CNC-lung interaction. Here, an Air Liquid Interface Cell Exposure system (ALICE), previously designed for studies of spherical nanoparticles, was used for the first time to establish a realistic physiological exposure test method for inhaled fiber shaped nano-objects; in this case, CNCs isolated from cotton. Applying a microscopy based approach the spatially homogenous deposition of CNCs was demonstrated as a prerequisite of the functioning of the ALICE. Furthermore, reliability and controllability of the system to nebulise high aspect ratio nanomaterials (HARN, e.g. CNCs) was shown. This opens the potential to thoroughly investigate the inhalatory risk of CNCs in vitro using a realistic exposure system. © IOP Publishing Ltd 2013.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
1742-6588
e-ISSN
1742-6596
Quellenangaben
Volume: 429,
Issue: 1,
Article Number: 012008,
Supplement: IOP
Publisher
Institute of Physics Publishing (IOP)
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)