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A mechanistic model for medulloblastoma induction in mice.
Radiat. Res. 179, 610-614 (2013)
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Medulloblastomas in Patched heterozygous mice (Ptc1(+/-) mice) are induced with high probability by ionizing radiation applied in the immediate post-natal period. A mathematical model is described here that accommodates the dependence of the medulloblastoma incidence on dose, age at exposure and age. The model assumes that the first step in the development of the cancer is already present in all cells of the patched mouse due to germ-line inactivation of one allele of the patched tumor suppressor gene. The subsequent rate-limiting step is dependent linearly on dose at least up to 3 Gy. The observed strong decrease in carcinogenic effect of radiation between exposure on day 1 and day 10 is described by a physiological elimination of target cells during post-natal maturation of the brain. A single malignant cell develops into a tumor following a gamma-distribution with mean of about 160 days. The multiplicity of medulloblastomas is predicted.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Lung-cancer; Mutation; Carcinogenesis; Radon; Cells; Risk
Language
english
Publication Year
2013
HGF-reported in Year
2013
ISSN (print) / ISBN
0033-7587
e-ISSN
1938-5404
Journal
Radiation Research
Quellenangaben
Volume: 179,
Issue: 5,
Pages: 610-614
Publisher
Radiation Research Society
Publishing Place
Lawrence
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Biology (ISB)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Radiation Sciences
PSP Element(s)
G-500200-001
PubMed ID
23560628
DOI
10.1667/RR3130.1
WOS ID
WOS:000330985900012
Scopus ID
84877000608
Erfassungsdatum
2013-07-31