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Open Access Green as soon as Postprint is submitted to ZB.
MALDI-TOF mass spectrometry.
Methods Mol. Biol. 1015, 71-85 (2013)
Major strengths of mass spectrometry analysis include the accuracy of the detection principle, automatic data storage as well as simplicity and flexibility of assay design making it a premier choice for targeted genotyping of sequence variations. We explain the assay principle in detail and give step-by-step laboratory instructions. Finally, references point toward further use of mass spectrometry analysis for molecular haplotyping, re-sequencing, and quantitative analysis for copy number variations and gene expression studies are given.
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Publication type
Article: Journal article
Document type
Scientific Article
Editors
Innocenti, F.* ; van Schaik, R.H.*
Keywords
Copy number variation; Gene expression; Haplotype; High-throughput genotyping; Matrix-assisted laser desorption/ionization mass spectrometry; Re-sequencing
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Conference Title
Pharmacogenomics : Methods and Protocols
Journal
Methods in Molecular Biology
Quellenangaben
Volume: 1015,
Pages: 71-85
Publisher
Springer
Publishing Place
Berlin [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)