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Neubert, P. ; Walch, A.K.

Current frontiers in clinical research application of MALDI imaging mass spectrometry.

Expert Rev. Proteomics 10, 259-273 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Imaging mass spectrometry (IMS) is still a relatively young imaging technique that allows molecular mapping of diverse biomolecules in their natural environment. Furthermore, IMS allows for the direct correlation of tissue histology and proteomic, metabolomic or lipidomic information. In recent years, increasing efforts have been made in the development and improvement of IMS, which aid its application in clinical research. In this article, current frontiers of clinical research applications of IMS are discussed in the context of recent developments of IMS technology. Critical stages in planning and realizing clinical studies are highlighted. Finally, a selection of recent prominent examples for successful clinical applications of IMS is presented.
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Publication type Article: Journal article
Document type Review
Keywords Clinical Proteomics ; Imaging Mass Spectrometry ; Maldi Imaging Mass Spectrometry ; Molecular Pathology ; Tissue Protein Analysis; Paraffin-embedded Tissue ; Matrix Application Method ; In-source Decay ; Breast-cancer ; Biomarker Discovery ; Protein Expression ; Drug Distribution ; Gastric-cancer ; Mouse-brain ; Intratumor Heterogeneity
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 1478-9450
e-ISSN 1744-8387
Journal Expert Review of Proteomics
Quellenangaben Volume: 10, Issue: 3, Pages: 259-273 Article Number: , Supplement: ,
Publisher Expert Reviews
Reviewing status Peer reviewed
Institute(s) Institute of Pathology (PATH)
Research Unit Analytical Pathology (AAP)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-500300-001
G-500390-001
PubMed ID 23777216
DOI 10.1586/epr.13.19
WOS ID WOS:000320708200013
Scopus ID 84879341172
Erfassungsdatum 2013-08-01
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