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Open Access Green as soon as Postprint is submitted to ZB.
Current frontiers in clinical research application of MALDI imaging mass spectrometry.
Expert Rev. Proteomics 10, 259-273 (2013)
Imaging mass spectrometry (IMS) is still a relatively young imaging technique that allows molecular mapping of diverse biomolecules in their natural environment. Furthermore, IMS allows for the direct correlation of tissue histology and proteomic, metabolomic or lipidomic information. In recent years, increasing efforts have been made in the development and improvement of IMS, which aid its application in clinical research. In this article, current frontiers of clinical research applications of IMS are discussed in the context of recent developments of IMS technology. Critical stages in planning and realizing clinical studies are highlighted. Finally, a selection of recent prominent examples for successful clinical applications of IMS is presented.
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Publication type
Article: Journal article
Document type
Review
Keywords
Clinical Proteomics ; Imaging Mass Spectrometry ; Maldi Imaging Mass Spectrometry ; Molecular Pathology ; Tissue Protein Analysis; Paraffin-embedded Tissue ; Matrix Application Method ; In-source Decay ; Breast-cancer ; Biomarker Discovery ; Protein Expression ; Drug Distribution ; Gastric-cancer ; Mouse-brain ; Intratumor Heterogeneity
ISSN (print) / ISBN
1478-9450
e-ISSN
1744-8387
Journal
Expert Review of Proteomics
Quellenangaben
Volume: 10,
Issue: 3,
Pages: 259-273
Publisher
Expert Reviews
Non-patent literature
Publications
Reviewing status
Peer reviewed