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Nyberg, S.T.* ; Fransson, E.I.* ; Heikkilä, K.* ; Alfredsson, L.* ; Casini, A.* ; Clays, E.* ; de Bacquer, D.* ; Dragano, N.* ; Erbel, R.* ; Ferrie, J.E.* ; Hamer, M.* ; Jöckel, K.-H.* ; Kittel, F.* ; Knutsson, A.* ; Ladwig, K.-H. ; Lunau, T.* ; Marmot, M.G.* ; Nordin, M.* ; Rugulies, R.* ; Siegrist, J.* ; Steptoe, A.* ; Westerholm, P.J.* ; Westerlund, H.* ; Theorell, T.* ; Brunner, E.J.* ; Singh-Manoux, A.* ; Batty, G.D.* ; Kivimaki, M.*

Job strain and cardiovascular disease risk factors: Meta-analysis of individual-participant data from 47,000 men and women.

PLoS ONE 8:e67323 (2013)
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BACKGROUND: Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain - heart disease association. METHODOLOGY AND PRINCIPAL FINDINGS: We pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following cardiovascular disease risk factors: diabetes, blood pressure, pulse pressure, lipid fractions, smoking, alcohol consumption, physical inactivity, obesity, and overall cardiovascular disease risk as indexed by the Framingham Risk Score. In age-, sex-, and socioeconomic status-adjusted analyses, compared to those without job strain, people with job strain were more likely to have diabetes (odds ratio 1.29; 95% CI: 1.11-1.51), to smoke (1.14; 1.08-1.20), to be physically inactive (1.34; 1.26-1.41), and to be obese (1.12; 1.04-1.20). The association between job strain and elevated Framingham risk score (1.13; 1.03-1.25) was attributable to the higher prevalence of diabetes, smoking and physical inactivity among those reporting job strain. CONCLUSIONS: In this meta-analysis of work-related stress and cardiovascular disease risk factors, job strain was linked to adverse lifestyle and diabetes. No association was observed between job strain, clinic blood pressure or blood lipids.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Coronary-heart-disease ; Ambulatory Blood-pressure ; 3-year Follow-up ; Whitehall-ii ; Work Stress ; Cohort ; Inequalities ; Mortality ; Swedish ; Profile
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 8, Issue: 6, Pages: , Article Number: e67323 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-003
PubMed ID 23840664
DOI 10.1371/journal.pone.0067323
WOS ID WOS:000322342800129
Scopus ID 84879259859
Erfassungsdatum 2013-08-01
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