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Open Access Green as soon as Postprint is submitted to ZB.
Automatic event detection within thrombus formation based on integer programming.
Lect. Notes Comput. Sc. 7766, Springer, 215-224 (2013)
After a blood vessel injury, blood platelets progressively aggregate on the damaged site to stop the resulting blood loss. This natural mechanism called thrombosis can however be prone to malfunctions and lead to the complete obstruction of the blood vessel. Thrombosis disorders play a crucial role in coronary artery diseases and the identification of genetic risk predispositions would therefore considerably help their diagnosis and therapy. In vitro experiments are conducted in this purpose by perfusing blood from several donors over a surface of collagen fibres, which results in the progressive attachment of platelets. Based on the segmentation over time of these aggregates called thrombi, we propose in this paper an automatic method combining tracking and event detection which allows the extraction of characteristics of interest for each thrombus growth individually, in order to find a potential correlation between these growth features and blood donors genetic disorders. We demonstrate the benefits of our approach and the accuracy of its results through an experimental validation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
event detection; Microscopy image analysis; multi-target tracking; thrombus segmentation
ISSN (print) / ISBN
0302-9743
e-ISSN
1611-3349
Quellenangaben
Volume: 7766,
Pages: 215-224,
Supplement: Springer
Publisher
Springer
Publishing Place
Berlin [u.a.]
Institute(s)
Institute of Computational Biology (ICB)