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Pulmonary surfactant is indispensable in order to simulate the in vivo situation.
Part. Fibre Toxicol. 10:6 (2013)
The article of Gasser et al. [Part Fibre Toxicol. 24; 9:17, 2012] describes the interaction of carbon nanotubes with cells within a complex cell culture model. Besides various toxicity parameters, the influence of coating with pulmonary surfactant was investigated. Pulmonary surfactant covers the entire alveolar region with the main function of decreasing the surface tension in the alveoli to prevent alveolar collapse. Although each inhaled nanoparticle, reaching the alveoli, will come into contact with pulmonary surfactant which will probably lead to a surfactant coating, pulmonary surfactant components are not commonly integrated in in vitro systems. Gasser and co-workers have shown that this surfactant coating is able to influence the further interaction with cellular systems. Hence, each scientist, working with in vitro systems and nanoparticles, should think of integrating pulmonary surfactant structures in order to harmonize the in vitro systems with the in vivo situation. In the present commentary we discuss the most important points of the manuscript of Gasser et al. and discuss where the usage of pulmonary surfactant can be further optimized.
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Publication type
Article: Journal article
Document type
Letter to the Editor
Keywords
Nanoparticle; Lung; Pulmonary surfactant; Coating; Walled Carbon Nanotubes ; Nanoparticles ; Vitro ; Lung ; Adsorption ; Lipids
ISSN (print) / ISBN
1743-8977
e-ISSN
1743-8977
Journal
Particle and Fibre Toxicology
Quellenangaben
Volume: 10,
Issue: 1,
Article Number: 6
Publisher
BioMed Central
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)