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Benedict, C.* ; Barclay, J.L.* ; Ott, V.* ; Oster, H.* ; Hallschmid, M.

Acute sleep deprivation delays the glucagon-like peptide 1 peak response to breakfast in healthy men.

Nutr. Diabetes 3:e78 (2013)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
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Objective:Previous experiments have demonstrated that acute sleep loss impairs glucose homeostasis and increases food intake in humans. The incretin hormone glucagon-like peptide 1 (GLP-1) enhances postprandial insulin secretion and promotes satiety. Hypothesizing that the detrimental metabolic effects of sleep curtailment imply alterations in GLP-1 signaling, we investigated 24-h serum total GLP-1 concentrations during total sleep deprivation (TSD) and a normal sleep/wake cycle (comprising ∼8 h of sleep) in 12 healthy young men.Methods:Sessions started at 1800 h, and subjects were provided with standardized meals. Assessments of serum GLP-1 took place in 1.5- to 3-h intervals, focusing on the response to breakfast intake (3.8 MJ).Results:Across conditions, 24-h concentration profiles of GLP-1 were characterized by the expected postprandial increases (P<0.001). Although there were no differences in magnitude between conditions (P>0.11), the postprandial GLP-1 peak response to breakfast intake was delayed by ∼90 min following sleep loss in comparison with regular sleep (P<0.02).Conclusions:Results indicate that acute TSD exerts a mild, but discernible effect on the postprandial dynamics of circulating GLP-1 concentrations in healthy men.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Glucagon-like peptide 1; Hormonal regulation; Sleep; Sleep deprivation; Type-2 Diabetes-mellitus ; Energy-expenditure ; Insulin-secretion ; Duration ; Food ; Increases ; Satiety ; Weight
e-ISSN 2044-4052
Journal Nutrition and Diabetes
Quellenangaben Volume: 3, Issue: , Pages: , Article Number: e78 Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)