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Open Access Green as soon as Postprint is submitted to ZB.
Argonaute and GW182 proteins: An effective alliance in gene silencing.
Biochem. Soc. Trans. 41, 855-860 (2013)
Argonaute proteins interact with small RNAs and facilitate small RNA-guided gene-silencing processes. Small RNAs guide Argonaute proteins to distinct target sites on mRNAs where Argonaute proteins interact with members of the GW182 protein family (also known as GW proteins). In subsequent steps, GW182 proteins mediate the downstream steps of gene silencing. The present mini-review summarizes and discusses our current knowledge of the molecular basis of Argonaute-GW182 protein interactions.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Argonaute proteine; Gene silencing; GW182 protein; microRNA; miRNA; RNA interference; RNAi; Messenger-rna Degradation ; Crystal-structure ; Structural Basis ; Guide Rna ; Translational Repression ; Piwi-domain ; Paz Domain ; Human Ago2 ; Gw Bodies ; P-bodies
ISSN (print) / ISBN
0300-5127
e-ISSN
1470-8752
Journal
Biochemical Society Transactions
Quellenangaben
Volume: 41,
Issue: 4,
Pages: 855-860
Publisher
Portland Press
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Structural Biology (STB)