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Artamonova, I.I. ; Gelfand, M.S.*

Comparative genomics and evolution of alternative splicing: The pessimists' science.

Chem. Rev. 107, 3407-3430 (2007)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Alternative splicing appears to be sciences' pessimist as nothing can reliably be identified along with its many other fundamental problems. On the brighter side, an optimism can still be seen as the splicing's noise provides material for selection of new and beneficial variants. The evolution of alternative splicing may allow various stages be fixed in different species. Specifically, the prevalence and function of alternative splicing is discussed. In addition, several other topics discussed include the evolution of exon-intron structure, the evolution of the alternative exon-intron structure and the functionality of nonconserved isoforms, the origin of alternative regions, the changes in alternative splicing after gene duplication, and lastly, the recognition of alternative exons and databases of alternative splicing.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2007
HGF-reported in Year 2007
ISSN (print) / ISBN 0009-2665
e-ISSN 1520-6890
Journal Chemical Reviews
Quellenangaben Volume: 107, Issue: 8, Pages: 3407-3430 Article Number: , Supplement: ,
Publisher American Chemical Society (ACS)
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)
PSP Element(s) G-503700-002
DOI 10.1021/cr068304c
Scopus ID 34548281651
Erfassungsdatum 2007-12-17
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