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Montrone, C. ; Kokkaliaris, K.D. ; Loeffler, D. ; Lechner, M. ; Kastenmüller, G. ; Schroeder, T. ; Ruepp, A.

HSC-Explorer: A curated database for hematopoietic stem cells.

PLoS ONE 8:e70348 (2013)
Publ. Version/Full Text Volltext DOI
Open Access Gold
Creative Commons Lizenzvertrag
HSC-Explorer (http://mips.helmholtz-muenchen.de/HSC/) is a publicly available, integrative database containing detailed information about the early steps of hematopoiesis. The resource aims at providing fast and easy access to relevant information, in particular to the complex network of interacting cell types and molecules, from the wealth of publications in the field through visualization interfaces. It provides structured information on more than 7000 experimentally validated interactions between molecules, bioprocesses and environmental factors. Information is manually derived by critical reading of the scientific literature from expert annotators. Hematopoiesis-relevant interactions are accompanied with context information such as model organisms and experimental methods for enabling assessment of reliability and relevance of experimental results. Usage of established vocabularies facilitates downstream bioinformatics applications and to convert the results into complex networks. Several predefined datasets (Selected topics) offer insights into stem cell behavior, the stem cell niche and signaling processes supporting hematopoietic stem cell maintenance. HSC-Explorer provides a versatile web-based resource for scientists entering the field of hematopoiesis enabling users to inspect the associated biological processes through interactive graphical presentation.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Bone-marrow Niche ; Self-renewal Capacity ; Progenitor Cells ; In-vivo ; Differentiation ; Representation ; Reconstitution ; Quiescence ; Networks ; Resource
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 8, Issue: 7, Pages: , Article Number: e70348 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)
Research Unit Stem Cell Dynamics (SCD)