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HSC-Explorer: A curated database for hematopoietic stem cells.
PLoS ONE 8:e70348 (2013)
HSC-Explorer (http://mips.helmholtz-muenchen.de/HSC/) is a publicly available, integrative database containing detailed information about the early steps of hematopoiesis. The resource aims at providing fast and easy access to relevant information, in particular to the complex network of interacting cell types and molecules, from the wealth of publications in the field through visualization interfaces. It provides structured information on more than 7000 experimentally validated interactions between molecules, bioprocesses and environmental factors. Information is manually derived by critical reading of the scientific literature from expert annotators. Hematopoiesis-relevant interactions are accompanied with context information such as model organisms and experimental methods for enabling assessment of reliability and relevance of experimental results. Usage of established vocabularies facilitates downstream bioinformatics applications and to convert the results into complex networks. Several predefined datasets (Selected topics) offer insights into stem cell behavior, the stem cell niche and signaling processes supporting hematopoietic stem cell maintenance. HSC-Explorer provides a versatile web-based resource for scientists entering the field of hematopoiesis enabling users to inspect the associated biological processes through interactive graphical presentation.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
3.730
1.148
8
11
Annotations
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Bone-marrow Niche ; Self-renewal Capacity ; Progenitor Cells ; In-vivo ; Differentiation ; Representation ; Reconstitution ; Quiescence ; Networks ; Resource
Language
english
Publication Year
2013
HGF-reported in Year
2013
ISSN (print) / ISBN
1932-6203
Journal
PLoS ONE
Quellenangaben
Volume: 8,
Issue: 7,
Article Number: e70348
Publisher
Public Library of Science (PLoS)
Publishing Place
Lawrence, Kan.
Reviewing status
Peer reviewed
Institute(s)
Institute of Bioinformatics and Systems Biology (IBIS)
Research Unit Stem Cell Dynamics (SCD)
Research Unit Stem Cell Dynamics (SCD)
POF-Topic(s)
30505 - New Technologies for Biomedical Discoveries
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Enabling and Novel Technologies
Stem Cell and Neuroscience
Stem Cell and Neuroscience
PSP Element(s)
G-503700-001
G-501200-001
G-501200-001
WOS ID
WOS:000323114200077
Scopus ID
84880841472
Erfassungsdatum
2013-08-08