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Kahle-Stephan, M. ; Horsch, M. ; Fridrich, B. ; Seelig, A. ; Schultheiß, J. ; Leonhardt, J. ; Irmler, M. ; Beckers, J. ; Rathkolb, B. ; Wolf, E.* ; Franke, N. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Neschen, S.

Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis.

Mol. Metab. 2, 435-446 (2013)
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Genetic predisposition and environmental factors contribute to an individual's susceptibility to develop hepatosteatosis. In a systematic, comparative survey we focused on genotype-dependent and -independent adaptations early in the pathogenesis of hepatosteatosis by characterizing C3HeB/FeJ, C57BL/6NTac, C57BL/6J, and 129P2/OlaHsd mice after 7, 14, or 21 days high-fat-diet exposure. Strain-specific metabolic responses during diet challenge and liver transcript signatures in mild hepatosteatosis outline the suitability of particular strains for investigating the relationship between hepatocellular lipid content and inflammation, glucose homeostasis, insulin action, or organelle physiology. Genetic background-independent transcriptional adaptations in liver paralleling hepatosteatosis suggest an early increase in the organ's vulnerability to oxidative stress damage what could advance hepatosteatosis to steatohepatitis. “Universal“ adaptations in transcript signatures and transcription factor regulation in liver link insulin resistance, type 2 diabetes mellitus, cancer, and thyroid hormone metabolism with hepatosteatosis, hence, facilitating the search for novel molecular mechanisms potentially implicated in the pathogenesis of human non-alcoholic-fatty-liver-disease.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Non-alcoholic fatty liver disease; Inflammation; Oxidative stress; Thyroid metabolism; Insulin resistance; Cancer
Language english
Publication Year 2013
HGF-reported in Year 0
ISSN (print) / ISBN 2212-8778
e-ISSN 2212-8778
Journal Molecular Metabolism
Quellenangaben Volume: 2, Issue: 4, Pages: 435-446 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Institute of Bioinformatics and Systems Biology (IBIS)
POF-Topic(s) 30201 - Metabolic Health
30505 - New Technologies for Biomedical Discoveries
90000 - German Center for Diabetes Research
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-500600-003
G-500600-001
G-500600-004
G-503700-001
G-501900-062
G-501900-064
PubMed ID 24327959
DOI 10.1016/j.molmet.2013.07.009
Scopus ID 84889099952
Erfassungsdatum 2013-08-12
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