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BNP as a marker dysfunction in the general population: Importance of left ventricular hypertrophy.
Eur. J. Heart Fail. 7, 525-531 (2005)
BNP is a marker of systolic left ventricular dysfunction (LVSD) and heart failure. To assess BNP for the detection of diastolic dysfunction in the general population, we examined 1678 subjects within an age- and sex-stratified survey (MONICA Augsburg). BNP was measured using a commercially available RIA (Shionogi).BNP increased in subjects with diastolic dysfunction (mean 20.3±4.7 pg/ml vs. control 9.6±0.5 pg/ml, p<0.001), but to a lesser extent than in subjects with LV hypertrophy (LVH, mean 37.3±49.1 pg/ml, p<0.001 vs. control) or LVSD (mean 76.2±23.2 pg/ml, p<0.001 vs. control). Individuals with sole diastolic abnormality displayed BNP concentrations at the control level (mean 9.7±1.7 pg/ml). In univariate analysis, age, BMI, systolic blood pressure, left atrial size, LV mass index, diastolic dysfunction and EF displayed a significant correlation with BNP (p<0.001). However, LV mass index displaced diastolic dysfunction as a significant predictor of BNP in multivariate analysis. Upon ROC analysis, sensitivity and specificity for the detection of diastolic dysfunction by BNP were only 61% and 55%, respectively. Nevertheless, a normal BNP test virtually excluded the presence of diastolic dysfunction and concomitant LVH (NPV 99.9%).Increased BNP concentrations in subjects with diastolic dysfunction are strongly related to LVH. Population-wide screening for diastolic dysfunction with BNP cannot be recommended although a normal BNP test usually excludes diastolic dysfunction and LV hypertrophy.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
heart failure; diastolic dysfunction; BNP; LV hypertrophy; echocardiography
Language
english
Publication Year
2005
HGF-reported in Year
2005
ISSN (print) / ISBN
1388-9842
e-ISSN
1879-0844
Quellenangaben
Volume: 7,
Issue: 4,
Pages: 525-531
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
POF-Topic(s)
30202 - Environmental Health
30202 - Environmental Health
Research field(s)
Genetics and Epidemiology
Genetics and Epidemiology
PSP Element(s)
G-503900-004
G-504090-001
G-504090-001
Erfassungsdatum
2005-09-27