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Anttila, V.* ; Winsvold, B.S.* ; Gormley, P.* ; Kurth, T.* ; Bettella, F.* ; McMahon, G.* ; Kallela, M.* ; Malik, R.* ; de Vries, B.* ; Terwindt, G.* ; Medland, S.E.* ; Todt, U.* ; McArdle, W.L.* ; Quaye, L.* ; Koiranen, M.* ; Ikram, M.A.* ; Lehtimäki, T.* ; Stam, A.H.* ; Ligthart, L.* ; Wedenoja, J.* ; Dunham, I.* ; Neale, B.M.* ; Palta, P.* ; Hämäläinen, E.* ; Schürks, M.* ; Rose, L.M.* ; Buring, J.E.* ; Ridker, P.M.* ; Steinberg, S.* ; Stefansson, H.* ; Jakobsson, F.* ; Lawlor, D.A.* ; Evans, D.M* ; Ring, S.M.* ; Färkkilä, M.* ; Artto, V.* ; Kaunisto, M.A.* ; Freilinger, T.* ; Schoenen, J.* ; Frants, R.R.* ; Pelzer, N.* ; Weller, C.M.* ; Zielman, R.* ; Heath, A.C.* ; Madden, P.A.* ; Montgomery, G.W.* ; Martin, N.G.* ; Borck, G.* ; Göbel, H.* ; Heinze, A.* ; Heinze-Kuhn, K.* ; Williams, F.M.* ; Hartikainen, A.L.* ; Pouta, A.* ; van den Ende, J.* ; Uitterlinden, A.G.* ; Hofman, A.* ; Amin, N.* ; Hottenga, J.J.* ; Vink, J.M.* ; Heikkilä, K.* ; Alexander, M.* ; Müller-Myhsok, B.* ; Schreiber, S.* ; Meitinger, T. ; Wichmann, H.-E. ; Aromaa, A.* ; Eriksson, J.G.* ; Traynor, B.J.* ; Trabzuni, D.* ; North American Brain Expression Consortium (*) ; UK Brain Expression Consortium (*) ; Rossin, E.* ; Lage, K.* ; Jacobs, S.B.* ; Gibbs, J.R.* ; Birney, E.* ; Kaprio, J.* ; Penninx, B.W.* ; Boomsma, D.I.* ; van Duijn, C.M.* ; Raitakari, O.* ; Jarvelin, M.R.* ; Zwart, J.A.* ; Cherkas, L.* ; Strachan, D.P.* ; Kubisch, C.* ; Ferrari, M.D.* ; van den Maagdenberg, A.M.* ; Dichgans, M.* ; Wessman, M.* ; Smith, G.D.* ; Stefansson, K.* ; Daly, M.J.* ; International Headache Genetics Consortium (*) ; Nyholt, D.R.* ; Chasman, D.I.* ; Palotie, A.*

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

Nat. Genet. 45, 912-917 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Transforming-growth-factor ; Neurite Outgrowth ; Down-regulation ; Human-disease ; Association ; Expression ; Protein ; Family ; Proteolysis ; Population
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 45, Issue: 8, Pages: 912-917 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)