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Dean-Ben, X.L. ; Ma, R. ; Rosenthal, A. ; Ntziachristos, V. ; Razansky, D.

Weighted model-based optoacoustic reconstruction in acoustic scattering media.

Phys. Med. Biol. 58, 5555-5566 (2013)

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Model-based optoacoustic inversion methods are capable of eliminating image artefacts associated with the widely adopted back-projection reconstruction algorithms. Yet, significant image artefacts might also occur due to reflections and scattering of optoacoustically-induced waves from strongly acoustically-mismatched areas in tissues. Herein, we modify the model-based reconstruction methodology to incorporate statistically-based weighting in order to minimize these artefacts. The method is compared with another weighting procedure termed half-image reconstruction, yielding generally better results. The statistically-based weighting is subsequently verified experimentally, attaining quality improvement of the optoacoustic image reconstructions in the presence of acoustic mismatches in tissue phantoms and small animals ex-vivo.

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