PuSH - Publication Server of Helmholtz Zentrum München

Fernández-Rhodes, L.* ; Demerath, E.W.* ; Cousminer, D.L.* ; Tao, R.* ; Dreyfus, J.G.* ; Esko, T.* ; Smith, A.V.* ; Gudnason, V.* ; Harris, T.B.* ; Launer, L.* ; McArdle, P.F.* ; Yerges-Armstrong, L.M.* ; Elks, C.E.* ; Strachan, D.P.* ; Kutalik, Z.* ; Vollenweider, P.* ; Feenstra, B.* ; Boyd, H.A.* ; Metspalu, A.* ; Mihailov, E.* ; Broer, L.* ; Zillikens, M.C.* ; Oostra, B.* ; van Duijn, C.M.* ; Lunetta, K.L.* ; Perry, J.R.* ; Murray, A.* ; Koller, D.L.* ; Lai, D.* ; Corre, T.* ; Toniolo, D.* ; Albrecht, E. ; Stöckl, D. ; Grallert, H. ; Gieger, C. ; Hayward, C.* ; Polasek, O.* ; Rudan, I.* ; Wilson, J.F.* ; He, C.* ; Kraft, P.* ; Hu, F.B.* ; Hunter, D.J.* ; Hottenga, J.J.* ; Willemsen, G.* ; Boomsma, D.I.* ; Byrne, E.M.* ; Martin, N.G.* ; Montgomery, G.W.* ; Warrington, N.M.* ; Pennell, C.E.* ; Stolk, L.* ; Visser, J.A.* ; Hofman, A.* ; Uitterlinden, A.G.* ; Rivadeneira, F.* ; Lin, P.* ; Fisher, S.L.* ; Bierut, L.J.* ; Crisponi, L.* ; Porcu, E.* ; Mangino, M.* ; Zhai, G.* ; Spector, T.D.* ; Buring, J.E.* ; Rose, L.M.* ; Ridker, P.M.* ; Poole, C.* ; Hirschhorn, J.N.* ; Murabito, J.M.* ; Chasman, D.I.* ; Widen, E.* ; North, K.E.* ; Ong, K.K.* ; Franceschini, N.*

Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.

Am. J. Epidemiol. 178, 451-460 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)(2)), waist circumference, and waist:hip ratio) single-nucleotide polymorphisms (SNPs) with age at menarche in 92,116 women of European descent from 38 studies (1970-2010), in order to estimate associations between genetic variants associated with central or overall adiposity and pubertal timing in girls. Investigators in each study performed a separate analysis of associations between the selected SNPs and age at menarche (ages 9-17 years) using linear regression models and adjusting for birth year, site (as appropriate), and population stratification. Heterogeneity of effect-measure estimates was investigated using meta-regression. Six novel associations of body mass index loci with age at menarche were identified, and 11 adiposity loci previously reported to be associated with age at menarche were confirmed, but none of the central adiposity variants individually showed significant associations. These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords adiposity; body mass index; genetic association studies; menarche; obesity; waist circumference; waist:hip ratio; women's health; Genome-wide Association ; Body-mass Index ; Waist Circumference ; Sequence Variants ; Age ; Obesity ; Loci ; Metaanalysis ; Risk ; Weight
ISSN (print) / ISBN 0002-9262
e-ISSN 1476-6256
Journal American Journal of Epidemiology
Quellenangaben Volume: 178, Issue: 3, Pages: 451-460 Article Number: , Supplement: ,
Publisher Oxford University Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)
Institute of Experimental Genetics (IEG)
Research Unit Molecular Epidemiology (AME)