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Linkage disequilibrium for different scales and applications.
Brief. Bioinform. 5, 1-10 (2004)
Assessing the patterns of linkage disequilibrium (LD) has become an important issue in both evolutionary biology and medical genetics since the rapid accumulation of densely spaced DNA sequence variation data in several organisms. LD deals with the correlation of genetic variation at two or more loci or sites in the genome within a given population. There are a variety of LD measures which range from traditional pairwise LD measures such as D′ or r2 to entropy-based multi-locus measures or haplotype-specific approaches. Understanding the evolutionary forces (in particular recombination) that generate the observed variation of LD patterns across genomic regions is addressed by model-based LD analysis. Marker type and its allelic composition also influence the observed LD pattern, microsatellites having a greater power to detect LD in population isolates than SNPs. This review aims to explain basic LD measures and their application properties.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
linkage disequilibrium measures; recombination rate variation; positive selection; microsatellites; SNPs
Language
english
Publication Year
2004
HGF-reported in Year
0
ISSN (print) / ISBN
1467-5463
e-ISSN
1477-4054
Journal
Briefings in Bioinformatics
Quellenangaben
Volume: 5,
Issue: 4,
Pages: 1-10
Publisher
Oxford University Press
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)
POF-Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500700-001
Erfassungsdatum
2004-12-09