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Schofield, P.N.* ; Bard, J.B.L.* ; Booth, C.* ; Boniver, J.* ; Covelli, V.* ; Delvenne, P.* ; Ellender, M.* ; Engstrom, W.* ; Goessner, W. ; Gruenberger, M.* ; Höfler, H.

Pathbase: A database of mutant mouse pathology.

Nucleic Acids Res. 32, D512-D515 (2004)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain-dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high-resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords GENE ONTOLOGY; BETHESDA PROPOSALS; BIOLOGY; CLASSIFICATION; NOMENCLATURE; NEOPLASMS; RESOURCE; MICE
ISSN (print) / ISBN 0305-1048
e-ISSN 1362-4962
Journal Nucleic Acids Research
Quellenangaben Volume: 32, Issue: , Pages: D512-D515 Article Number: , Supplement: ,
Publisher Oxford University Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Pathology (PATH)