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Open Access Green as soon as Postprint is submitted to ZB.
Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain.
Nat. Neurosci. 16, 1370-1372 (2013)
To examine the role of gray and white matter niches for oligodendrocyte differentiation, we used homo- and heterotopic transplantations into the adult mouse cerebral cortex. White matter-derived cells differentiated into mature oligodendrocytes in both niches with equal efficiency, whereas gray matter-derived cells did not. Thus, white matter promotes oligodendrocyte differentiation, and cells from this niche differentiate more easily, even in the less supportive gray matter environment.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cerebral-cortex ; Nervous-system ; White-matter ; Rat Cns ; Cells ; Progenitors ; Lineage ; Mouse ; Mice ; Expression
ISSN (print) / ISBN
1097-6256
e-ISSN
1546-1726
Journal
Nature Neuroscience
Quellenangaben
Volume: 16,
Issue: 10,
Pages: 1370-1372
Publisher
Nature Publishing Group
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)