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Laxy, M. ; Holle, R. ; Döring, A. ; Petter, A. ; Hunger, M.

The longitudinal association between weight change and health-related quality of life: The KORA S4/F4 cohort study.

Int. J. Public Health 59, 279-288 (2014)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVES: Despite the increasing importance of patient-centered perspectives, the impact of weight change on the health-related quality of life (HRQL) has remained unclear. This work aims to investigate this longitudinal relationship. METHODS: Data was collected from a population-based cohort study of 3,080 Germans. Anthropometrics and HRQL were assessed at baseline and after a 7-year follow-up period. Using linear regression the average change in HRQL scores was calculated among 5 mutually exclusive weight change groups. Multilevel growth modeling was conducted to differentiate between interpersonal (cross-sectional) and intrapersonal (longitudinal) associations between body mass index (BMI)/BMI change and HRQL. RESULTS: Heavy weight gain (≥10 % body weight) was associated with impairments in physical health among women (-2.82 points, CI: -4.29, -1.34) and obese men (-4.33 points, CI: -7.62, -1.04) and with improvements in mental health among women (+3.20 points, CI: +1.37, +5.02). Results from the multilevel models were consistent, showing negative associations between BMI change and physical health, positive associations between BMI change and mental health and a high degree of similarity between interpersonal and intrapersonal associations. CONCLUSIONS: Weight gain leads to clinically relevant impairments in physical health. More research is needed to clarify the antipodal effects of weight change on physical and mental health components.  
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Health-related quality of life; Weight change; Obesity; Longitudinal; Population-based; Body-weight; Iqola Project; Obesity; Population; Impact; Overweight; Hypertension; Countries; Mass
ISSN (print) / ISBN 0303-8408
e-ISSN 1420-911X
Journal International Journal of Public Health
Quellenangaben Volume: 59, Issue: 2, Pages: 279-288 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Basel
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Health Economics and Health Care Management (IGM)
Institute of Epidemiology (EPI)
German Center for Diabetes Reseach (DZD)