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De-novo design of antimicrobial peptides for plant protection.

PLoS ONE 8:e71687 (2013)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
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This work describes the de-novo design of peptides that inhibit a broad range of plant pathogens. Four structurally different groups of peptides were developed that differ in size and position of their charged and hydrophobic clusters and were assayed for their ability to inhibit bacterial growth and fungal spore germination. Several peptides are highly active at concentrations between 0,1 and 1 mg/ml against plant pathogenic bacteria, such as Pseudomonas syringae, Pectobacterium carotovorum, and Xanthomonas vesicatoria. Importantly, no hemolytic activity could be detected for these peptides at concentrations up to 200 mg/ml. Moreover, the peptides are also active after spraying on the plant surface demonstrating a possible way of application. In sum, our designed peptides represent new antimicrobial agents and with the increasing demand for antimicrobial compounds for production of "healthy" food, these peptides might serve as templates for novel antibacterial and antifungal agents.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gram-positive Bacteria ; Cationic Peptide ; Phytopathogenic Bacteria ; Biological-activity ; Disease Control ; Pore Formation ; Magainin-ii ; Cecropin-b ; Resistance ; Expression
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 8, Issue: 8, Pages: , Article Number: e71687 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Non-patent literature Publications
Reviewing status Peer reviewed