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Open Access Green as soon as Postprint is submitted to ZB.
Analytical approaches for an important shellfish poisoning agent: Domoic acid.
J. Agric. Food Chem. 58, 11525-11533 (2010)
Domoic acid (DA), a neurotoxic amino acid produced by some strains of phytoplankton, is responsible for the human toxic syndrome amnesic shellfish poisoning. This exocitotoxin results in neuronal degeneration and necrosis in specific regions of the hippocampus. Because DA accumulates mostly in shellfish, causing outbreaks in different countries, screening for DA has been carried out with various assays. Although bioassays and immunoassays have been developed, several liquid chromatographic methods for the determination of DA in different matrices such as shellfish, algae, or seawater have been reported. Additionally, other alternative methods such as capillary electrophoresis and capillary electrochromatography have been described. This paper summaries the toxicology, the chemistry, and the developed determination methods of DA.
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Publication type
Article: Journal article
Document type
Review
Keywords
Domoic acid; shellfish poisoning; determination; sample preparation; HPLC; CE; CEC
Language
english
Publication Year
2010
HGF-reported in Year
2010
ISSN (print) / ISBN
0021-8561
e-ISSN
1520-5118
Quellenangaben
Volume: 58,
Issue: 22,
Pages: 11525-11533
Publisher
American Chemical Society (ACS)
Publishing Place
Washington, DC
Reviewing status
Peer reviewed
Institute(s)
Institute of Ecological Chemistry (IOEC)
PSP Element(s)
G-505100-007
G-505190-001
G-505190-001
PubMed ID
20964434
Scopus ID
78649233647
Erfassungsdatum
2010-12-31