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Wagner, R. ; Thorand, B. ; Osterhoff, M.A. ; Müller, G. ; Böhm, A. ; Meisinger, C. ; Kowall, B. ; Rathmann, W. ; Kronenberg, F.* ; Staiger, H. ; Stefan, N. ; Roden, M. ; Schwarz, P.E. ; Pfeiffer, A.F. ; Häring, H.-U. ; Fritsche, A.

Family history of diabetes is associated with higher risk for prediabetes: A multicentre analysis from the German Center for Diabetes Research.

Diabetologia 56, 2176-2180 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
AIMS/HYPOTHESIS: Prediabetes is a collective term for different subphenotypes (impaired glucose tolerance [IGT] and/or impaired fasting glucose [IFG]) with different pathophysiologies. A positive family history for type 2 diabetes (FHD) is associated with increased risk for type 2 diabetes. We assumed that it would also associate with prediabetes, but wondered whether all subphenotypes are related to a positive family history. METHODS: In a study population of 8,106 non-diabetic individuals of European origin collected from four study centres (normal glucose tolerance, NGT n = 5,482, IFG and/or IGT n = 2,624), we analysed whether having at least one first degree relative with diabetes is associated with prediabetes. The analyses were performed using the same models in each population separately. Afterwards, a meta-analysis was performed. RESULTS: FHD was significantly associated with the risk for prediabetes (IFG and/or IGT, OR 1.40; 95% CI 1.27, 1.54). This association remained significant in multivariable logistic regression models including sex, age and BMI (OR 1.26; 95% CI 1.14, 1.40). When different prediabetic outcomes were considered separately, the association was found for isolated IFG (OR 1.37; 95% CI 1.20, 1.57), isolated IGT (OR 1.25; 95% CI 1.07, 1.46) as well as for the combination IFG+IGT (OR 1.64; 95% CI 1.40, 1.93). After stratification on BMI, association between FHD and prediabetes was seen only in non-obese individuals (BMI < 30 kg/m(2)). CONCLUSIONS/INTERPRETATION: We found that FHD is an important risk factor for prediabetes, especially for combined IGT and IFG. Its relevance seems to be more evident in the non-obese.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Dzd ; Family History ; German Center For Diabetes Research ; Ifg ; Igt ; Meta-analysis ; Prediabetes; Life-style Factors ; Type-2 ; Predict ; Women ; Score
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 0012-186X
e-ISSN 1432-0428
Journal Diabetologia
Quellenangaben Volume: 56, Issue: 10, Pages: 2176-2180 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin ; Heidelberg [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Epidemiology (EPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
30202 - Environmental Health
Research field(s) Helmholtz Diabetes Center
Genetics and Epidemiology
PSP Element(s) G-502400-001
G-504000-002
G-504000-006
G-501900-401
PubMed ID 23979484
DOI 10.1007/s00125-013-3002-1
WOS ID WOS:000324062800010
Scopus ID 84890129078
Erfassungsdatum 2013-09-24
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