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Open Access Green as soon as Postprint is submitted to ZB.
DMSO enhances electrospray response, boosting sensitivity of proteomic experiments.
Nat. Methods 10, 989-991 (2013)
We report that low percentages of dimethylsulfoxide (DMSO) in liquid chromatography solvents lead to a strong enhancement of electrospray ionization of peptides, improving the sensitivity of protein identification in bottom-up proteomics by up to tenfold. The method can be easily implemented on any LC-MS/MS system without modification to hardware or software and at no additional cost.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Mass-spectrometry ; Peptide Identification ; Nanoelectrospray ; Ionization ; Molecules
ISSN (print) / ISBN
1548-7091
e-ISSN
1548-7105
Journal
Nature Methods
Quellenangaben
Volume: 10,
Issue: 10,
Pages: 989-991
Publisher
Nature Publishing Group
Publishing Place
New York, NY
Reviewing status
Peer reviewed