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MacIntyre, E.A. ; Carlsten, C.* ; Macnutt, M.* ; Fuertes, E. ; Melén, E.* ; Tiesler, C.M. ; Gehring, U.* ; Krämer, U.* ; Klümper, C.* ; Kerkhof, M.* ; Chan-Yeung, M.* ; Kozyrskyj, A.L.* ; Berdel, D.* ; Bauer, C.P.* ; Herbarth, O.* ; Bauer, M. ; Schaaf, B.* ; Koletzko, S.* ; Pershagen, G.* ; Brunekreef, B.* ; Heinrich, J. ; Brauer, M.*

Traffic, asthma and genetics: Combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma.

Eur. J. Epidemiol. 28, 597-606 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Associations between traffic-related air pollution and incident childhood asthma can be strengthened by analysis of gene-environment interactions, but studies have typically been limited by lack of study power. We combined data from six birth cohorts on: asthma, eczema and allergic rhinitis to 7/8 years, and candidate genes. Individual-level assessment of traffic-related air pollution exposure was estimated using land use regression or dispersion modeling. A total of 11,760 children were included in the Traffic, Asthma and Genetics (TAG) Study; 6.3 % reported physician-diagnosed asthma at school-age, 16.0 % had asthma at anytime during childhood, 14.1 % had allergic rhinitis at school-age, 10.0 % had eczema at school-age and 33.1 % were sensitized to any allergen. For GSTP1 rs1138272, the prevalence of heterozygosity was 16 % (range amongst individual cohorts, 11-17 %) and homozygosity for the minor allele was 1 % (0-2 %). For GSTP1 rs1695, the prevalence of heterozygosity was 45 % (40-48 %) and homozygosity for the minor allele, 12 % (10-12 %). For TNF rs1800629, the prevalence of heterozygosity was 29 % (25-32 %) and homozygosity for the minor allele, 3 % (1-3 %). TAG comprises a rich database, the largest of its kind, for investigating the effect of genotype on the association between air pollution and childhood allergic disease.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Air Pollution ; Gstp1 ; Tnf ; Asthma ; Wheeze ; Gene-environment; S-transferase P1 ; Geographic Information-systems ; Land-use Regression ; 3 European Areas ; Allergic Sensitization ; Respiratory Health ; Children ; Contrasts ; Symptoms ; Exposure
ISSN (print) / ISBN 0393-2990
e-ISSN 1573-7284
Journal European Journal of Epidemiology
Quellenangaben Volume: 28, Issue: 7, Pages: 597-606 Article Number: , Supplement: ,
Publisher Springer
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)